The Midwest — America's Innovation Heartland
Explore the investors, startups, accelerators, universities, research institutions, public programs and innovation communities shaping the U.S. Midwest.
105 of 243 organizations shown · 105 in map view
105 of 243 organizations
| Organization | Type | Location | Scope | Focus | Actions |
|---|---|---|---|---|---|
| P33 | Ecosystem Hub | Chicago, Illinois | Regional | Regional tech ecosystem | |
| World Business Chicago | Government & Public Funding | Chicago, Illinois | Regional | Economic development | |
| 1871 | Accelerator / Incubator | Chicago, Illinois | Regional | Innovation hub | |
| mHUB | Accelerator / Incubator | Chicago, Illinois | Regional | Hardtech innovation hub | |
| MATTER | Accelerator / Incubator | Chicago, Illinois | Regional | Healthtech incubator | |
| Polsky Center for Entrepreneurship and Innovation | Research & University | Chicago, Illinois | Regional | University entrepreneurship | |
| Chicago Quantum Exchange | Research & University | Chicago, Illinois | Regional | Quantum ecosystem | |
| Discovery Partners Institute | Research & University | Chicago, Illinois | Regional | University/research innovation | |
| Techstars Chicago | Accelerator / Incubator | Chicago, Illinois | Regional | Accelerator program | |
| Duality | Accelerator / Incubator | Chicago, Illinois | Regional | Quantum accelerator | |
| Portal Innovations | Accelerator / Incubator | Chicago, Illinois | Regional | Life sciences venture development | |
| University of Chicago | Research & University | Chicago, Illinois | Regional | University | |
| Northwestern University | Research & University | Evanston, Illinois | Regional | University | |
| Querrey InQbation Lab | Research & University | Evanston, Illinois | Regional | University innovation hub | |
| University of Illinois Chicago | Research & University | Chicago, Illinois | Regional | University | |
| UIC Spark Innovation Hub | Research & University | Chicago, Illinois | Regional | University innovation hub | |
| Illinois Institute of Technology | Research & University | Chicago, Illinois | Regional | University | |
| Kaplan Institute for Innovation and Tech Entrepreneurship | Research & University | Chicago, Illinois | Regional | University innovation hub | |
| Loyola University Chicago | Research & University | Chicago, Illinois | Regional | University | |
| Ignite Lab | Research & University | Chicago, Illinois | Regional | University innovation hub | |
| Argonne National Laboratory | Research & University | Lemont, Illinois | Regional | National laboratory | |
| Fermi National Accelerator Laboratory | Research & University | Batavia, Illinois | Regional | National laboratory | |
| MxD | Ecosystem Hub | Chicago, Illinois | Regional | Advanced manufacturing innovation | |
| ARCH Venture Partners | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Chicago Ventures | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Hyde Park Venture Partners | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Lightbank | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Jump Capital | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| OCA Ventures | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Origin Ventures | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| MATH Venture Partners | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| M25 | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Corazon Capital | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Impact Engine | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Moderne Ventures | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Energize Capital | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| S2G Investments | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| 7wireVentures | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| Second Century Ventures | VC Fund | Chicago, Illinois | Regional | Venture capital | |
| TechNexus Venture Collaborative | VC Fund | Chicago, Illinois | Regional | Venture capital |
Midwest ecosystem data assembled by StartupFuel from public ecosystem directories, state and regional innovation sources, organization websites and StartupFuel research. Data is continuously being expanded and corrected.Last updated October 2026
The Midwest's innovation ecosystem, connected.
Capital, companies, accelerators, research institutions, universities, public infrastructure, corporate innovation and ecosystem communities building technology across America's Midwest.
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